When you install the BigMIND desktop software on your Windows machine, you will find that a new folder with the name of No-BigMIND Zone has been created on your desktop.

You can use this No-BigMIND Zone folder to prevent BigMIND from backing up certain files/folders by simply drag/drop them into it. This way, if you select to back up your entire desktop, BigMIND will not upload the content of this No-BigMIND Zone folder.